Complement-Fixation Tests with Cell Lines Derived from Burkitt's Lymphoma and Acute Leukemias

Complement Fixation Tests in Pertussis.

Bordet and Gengou (1), in 1906, performed serological tests on pertussis employing the organisms which they discovered and claimed to be the causative agent of whooping cough as the antigen for the complement fixation test. They got a positive reaction in most cases of the disease. Yet, later investigations failed to confirm these results. Among those who confirmed their results were Renaux (2)...

Complement Fixation Tests in Poliomyelitis **

Infection with poliomyelitis virus gives rise to complement-fixing (C-F) antibodies which may be detected with antigens prepared either from the brains of infected mice or tissue culture fluids, as shown with Type II by Casals et al."' and with all three types by Svedmyr et al.' These workers used sufficient antigen in each test to obtain maximum sensitivity. With this antigen concentration the...

Complement-fixing antigens in Burkitt lymphoma cell lines.

The complement-fixing (CF) activity of antigens from cultured Burkitt lymphoma cells was determined by using normal American sera as the source of antibody. Approximately 75% of the sera fixed complement with the positive cell lines. These lines contained the herpes-like virus detectable by electron microscopy. The content of CF antigen depended on the cell line used but appeared to be independ...

Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias.

Session 4 of the 2005 Society of Hematopathology/European Association for Haematopathology Workshop focused on case presentations of precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (pre-T ALL/LBL) and acute biphenotypic leukemia. Pre-T ALL represents approximately 15% of childhood and 25% of adult ALL cases. Pre-T LBL comprises 85% to 90% of LBL and frequently manifests as ...

Cat scratch disease: results of complement-fixation and skin tests.